Parkinson's disease is the fastest growing neurodegenerative disorder
1. Motor symptoms
Tremor – a shaking of the hands, arms, or legs.
Rigidity – abnormal stiffness in a part of the body
Postural instability – impaired balance or difficulty standing or walking
Bradykinesia – gradual loss and slowing down of spontaneous movement
2. Non-motor symptoms
Examples of non-motor symptoms include fatigue, depression, apathy, difficulty swallowing or chewing, urinary problems, constipation, loss of smell, sleep problems, pain, and cognitive problems.
3. Quality of Life
Quality of Life (QoL) is a multi-dimensional construct, which consists of at least three broad domains: physical, mental and social.
QoL specifically focuses on the impact of an illness and/or treatment on patients’ perception of their status of health and on subjective well-being or satisfaction with life.
Globally, neurological disorders are the leading cause of disability.
An estimated 10 million people are diagnosed with Parkinson’s disease worldwide, and this does not consider the millions that are already living with Parkinson’s without being diagnosed. Recent forecasts estimate a doubling of patients in the next generation.
The annual cost of Parkinson’s disease in the United States alone is estimated at $52 billion for 1 million people living with the disease.
51 disease-modifying therapies and 48 symptomatic therapies are in clinical testing, the global pharma market for Parkinson’s is estimated to grow to $6 billion by 2022.
A 2013 study supported by the American Academy of Neurology (AAN) showed an 11% shortage in neurologists at that time and projected a 19% shortage by 2025.